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Fundamentally there is very good evidence now that laughter made by jokes can adjust the chemical milieu that courses through our physique on a second to second basis, and in profound degree.

Laughter releases natural endorphins that act on the same receptors as morphine that produce the feelings of relaxation and heightened mood. Levels of Dopamine, serotonin, and Nor- epinephrine are altered also that make endogenous anti- depressant impact.